22 Jun 2021 9:04 AM +00:00

Warframe Nidus Guide - How to Obtain, Craft, and Best Builds

The corrupted Nidus is a great warframe that can use his parasitic abilities for survival, crowd control, and also wipe any room, excelling as an offensive character in any context or mission. His tankiness/immortality gives him great potential for soloing content, even in the endgame missions, and he can work great in a team as well.

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How to Craft Nidus?

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Nidus' main blueprint is acquired from “The Glast Gambit” quest, additional main blueprints can be bought from Cephalon Simaris for 50,000 Reputation. Nidus' component blueprints are acquired from Rotation C of Infested Salvage on Oestrus, Eris.

Building Requirements
Nidus Blueprint Price - The Glast Gambit Quest Reward
Nidus Neuroptics - Drop Chance 14.29% - Rotation C Salvage - Oestrus, Eris
Nidus Chassis - Drop Chance 14.29% - Rotation C Salvage - Oestrus, Eris
Nidus Systems - Drop Chance 14.29% - Rotation C Salvage - Oestrus, Eris

Building Time
Warframe- 72 Hours
Components - 12 Hours

Nidus Overview and Best Weapon Options

Nidus is a very tanky warframe that has the potential of just not dying thanks to his passive. His abilities not only give him great survivability but also offensive power and crowd control tools, making him a very complete warframe and a great addition to any team or solo missions.


The Infestation dwelling within Nidus mutates rapidly when used against his foes, fueling his abilities and yielding various symbiotic benefits.

Mutation Stacks are a resource unique to Nidus, indicated by the Mutation counter and gauge displayed in the lower-right on the HUD, above the ability icons. The gauge is divided into five sections which represent the number of hits dealt to enemies via Nidus' abilities. The counter at the center of the gauge keeps track of the number of Mutation stacks, capping at 100.

Upon hitting one or more enemies via Virulence or Ravenous, depending on the number of hits the sections of the gauge will light up clockwise. After a total of 5 hits, the gauge completes a cycle and the sections become unlit again, while the counter increases by 1 Mutation stack. If Nidus suffers fatal damage with at least 15 stacks of Mutation, those 15 stacks are consumed, granting him 5 seconds of invulnerability and restoring 50% of his health.

Rupture the ground with a damaging fungal growth that steals energy from each enemy it strikes. For every five enemies hit, the Infestation mutates, multiplying its destructive force. Strength: 150 / 160 / 175 / 200 Damage
Range: 10 / 11 / 13 / 16 Meters
4 Meters of fungal growth width
25% Energy refund rate per hit

Spawn an Infested pod that erupts with tendrils, latches onto nearby enemies, and pulls them in. Enemies killed while held have a chance of generating a Mutation stack.
Duration: 4 / 5 / 6 / 7 Seconds
Range: 8 / 9 / 10 / 12 Meters of grab radius
Misc: 3 Seconds of unaffected targets release delay

Parasitic Link
Bind to a target with a parasitic link. When cast on an ally, both the host and Nidus have their Ability Strength increased. Linked enemies take some of the damage inflicted on Nidus.
Mutation Stacks Cost: 1
10% / 15% / 20% / 25% Strength bonus
20% / 30% / 40% / 50% Damage redirection
Duration: 30 / 35 / 45 / 60 Seconds
24 / 28 / 34 / 40 Meters of ally link
10 / 13 / 16 / 20 Meters of enemy link

Gluttonous maggots swarm nearby enemies, feasting until they burst with Infestation. The maggots benefit from Mutation and each enemy consumed adds to the Mutation stack.
Mutation Stacks Cost: 3
100 / 110 / 125 / 150 Blast damage
10 / 13 / 16 / 20 Health regeneration per second
Duration: 25 / 30 / 35 / 40 Seconds
Range: 4 Meters of explosion radius
8 Meters of ability diameter
Number of maggots: 9
Maggot health: 1000 HP
Maggot Toxin damage: 10

Recommended Weapons
Since Nidus’ build relies on his skills more than weapons, you can use any setup on this part. Acceltra, Epitaph, and Orthos will serve their roles perfectly, and of course, if you can afford the Prime or Vandal versions, the better. Use as many Forma on them as you see fit to achieve the desired build, and you'll be good to go!

Primary Weapon - Acceltra

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Secondary Weapon - Epitaph

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Melee Weapon - Orthos

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Nidus Best Builds

Nidus - Solo Build

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Mods List
Aura Mod - Energy Siphon/Enemy Radar/Corrosive Projection
Exilus Mod - Power Drift

  • Continuity
  • Hunter Adrenaline/Flow
  • Vitality
  • Steel Fiber
  • Stretch
  • Augur Reach
  • Intensify
  • Adaptation

The idea of the build is to use Nidus’ abilities as you see fit in the moment, prioritizing obtaining stacks so you benefit from them as soon as possible. To do this, focus on powering up the Range, Duration, and Strength as much as you can without taking any negative stat as a consequence. Since Nidus doesn’t have shields you need to boost his armor and health and use Parasitic Link at all times, always. While Hunter Adrenaline should work better than Flow in later stages of the game, it’s up to you which one to use, and for dramatically better results, replace the mods in this setup with their Prime or Umbral versions.